July 18, 2022

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To describe trends in 10-year cancer survival from childhood cancers diagnosed over 10 years (2002-2011) in Australia, and investigate the influence of demographic and tumour factors on these trends. Data on 4,464 children and adolescents aged 0-19 years were derived from the International Classification of Childhood and Adolescent Cancers Registry (ICCCR) based on diagnoses recorded in the Australian Childhood Cancer Registry (ACC). Trends over time in 10-year survival for children and adolescents with childhood and adolescent cancers diagnosed during 2002-2011 were compared using a log-rank test, and survival was modelled using competing risks regression. The 5-year survival rate for children and adolescents with CNS cancers was significantly higher in the most recent period, 2008-2011 (91.7%; 95% CI: 88.3-93.9) compared with the preceding 5-year period, 2001-2005 (80.2%; 95% CI: 77.5-83.1), and to the preceding 20-year period, 1971-1990 (67.8%; 95% CI: 63.8-71.7). A significant increase in survival from children and adolescents with leukaemia was also observed during 2008-2011 compared with the preceding period, 2001-2005 (81.8%; 95% CI: 75.5-87.5). No trends in the survival of other specific types of childhood cancer were evident. Ten-year survival from childhood cancers diagnosed in childhood and adolescence in Australia has improved since 2001, particularly for some types of cancer (CNS and leukaemia).Endogenous opioid peptides and the cardiovascular system.
This review evaluates the evidence for the direct actions of endogenous opioid peptides (EOP) on the heart and blood vessels, with special focus on those effects occurring in the face of either elevated or reduced pressure of arterial perfusion. The development of our knowledge of the latter was in some ways the most exciting since the first papers were published in which EOP were proposed to be of importance in this area. Three main areas are discussed, namely a) vasodepressor actions; b) action at the level of baroreceptors or chemoreceptors; c) mediation

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Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the components of the extracellular matrix (ECM). Of the many MMPs known, only the gelatinases MMP-2 and MMP-9 have been sufficiently characterized to justify review. This paper summarizes the discovery, preclinical efficacy, and pharmacology of MMP inhibitors, with an emphasis on those relevant to cardiovascular disease. Special emphasis will be placed on high-throughput screening, structure-activity relationships, pharmacokinetics, and the preclinical and clinical studies of pharmaceuticals that have been developed with an emphasis on their efficacy and safety. Although the inhibitors discussed here were mostly developed by pharmaceutical companies, many of their basic mechanistic insights came from academic laboratories.Q:

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